Brivaracetam

Key Product Details

Product Description

Brivaracetam is an antiepileptic compound that is a ligand for synaptic vesicle glycoprotein 2A (SV2A; K_d = 50 nM for human SV2A in vitro). Brivaracetam displays selectivity for SV2A at 10 μM, against a panel of 55 receptors, enzymes, ion channels and transporters. In mice, Brivaracetam protects against clonic audiogenic seizures.

Product Specifications for Brivaracetam

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Brivaracetam

The following data is based on the product molecular weight 212.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.71 mL	23.55 mL	47.11 mL
5 mM	0.94 mL	4.71 mL	9.42 mL
10 mM	0.47 mL	2.36 mL	4.71 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Rogawski A new SV2A ligand for epilepsy. Cell. 2016 PMID: 27768878
• Gillard Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties. Eur.J.Pharmacol. 2011 PMID: 21575627

Product Documents for Brivaracetam