BRL 44408 maleate

Key Product Details

Product Description

BRL 44408 maleate is a selective α_2A-adrenoceptor antagonist (K_i = 1.7 nM and 144.5 nM at α_2A and α_2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for BRL 44408 maleate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for BRL 44408 maleate

The following data is based on the product molecular weight 331.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.18 mL
5 mM	0.60 mL	3.02 mL	6.04 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

• Young Novel α₂-adrenoceptor antagonists show selectivity for α_2A- and α_2B-adrenoceptor subtypes. Eur.J.Pharmacol. 1989 PMID: 2573535
• Gavin α_2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089673
• Kiss Subtype-specificity of the presynaptic α₂-adrenoceptors modulating hippocampal NE release in rat. Brain Res. 1995 PMID: 7796102
• Callado α_2A-But not α_2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data. Eur.J.Pharmacol. 1999 PMID: 10064149

Product Documents for BRL 44408 maleate