BromoCatch™ Ligand, Alkyne

Tocris Bioscience | Catalog # 8940

Clickable alkyne-functionalized covalent probe for BromoCatch-tagged proteins
Tocris Bioscience

Key Product Details

Description

Clickable alkyne-functionalized covalent probe for BromoCatch-tagged proteins
View all BromoCatch Platform »

Product Description

BromoCatch™ Ligand, Alkyne is a covalent ligand engineered to irreversibly bind BromoCatch-tagged proteins via selective reaction with the E438C cysteine mutant of the Brd4-BD2 domain. Featuring a terminal alkyne appended to the BromoCatch Ligand scaffold, this ligand enables downstream modification through copper-catalyzed azide-alkyne cycloaddition (CuAAC). BromoCatch™ Ligand, Alkyne facilitates modular tagging of BromoCatch fusions with fluorophores, biotin, affinity tags, or functional moieties, offering a flexible platform for custom probe development. It enables site-specific protein labeling in vitro and is ideal for applications in chemical biology, proteomics, and multiplexed detection assays.

Please refer to this protocol for further information on how to use this product.

This product is part of an early adopter program.

BromoCatch™ is a trademark of Bio-Techne Corp.

Licensing Information

Sold under exclusive licence from the University of Dundee

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Product Specifications for BromoCatch™ Ligand, Alkyne

Molecular Weight

632.78

Formula

C33H40N6O5S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(2R)-2-((6S)-4-(4-Acrylamidophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)butanamide

InChI Key

OFMNYRGCADESPS-VIZCGCQYSA-N

SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)NC(C=C)=O)=N[C@@H]([C@H](C(NCCOCCOCCOCC#C)=O)CC)C4=NN=C(C)N24

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for BromoCatch™ Ligand, Alkyne

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BromoCatch™ Ligand, Alkyne

For research use only

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