BTT 3033

Tocris Bioscience | Catalog # 4724

Selective inhibitor of integrin α2β1
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of integrin α2β1
View all Integrin Receptor Inhibitors »

Product Description

BTT 3033 is a selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow and inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Neurogenic and thromboxane A2-induced human prostate smooth muscle contraction are also inhibited by BTT 3033.

Product Specifications for BTT 3033

Molecular Weight

465.50

Formula

C23H20FN5O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide

CAS Number

1259028-99-3

PubChem ID

49841251

InChI Key

NSLIQOPYDUKWTA-UHFFFAOYSA-N

SMILES

FC1=CC=C(N2N=CC(S(N(C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)C)(=O)=O)=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.55 100

Preparing Stock Solutions for BTT 3033

The following data is based on the product molecular weight 465.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.30 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

Product Documents for BTT 3033

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BTT 3033

For research use only

Customer Reviews for BTT 3033 (1)

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  • Collagen type 1 activated collagen receptor discoidin domain receptor
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: 3D Culture Matrix
    Verified Customer | Posted 02/21/2020
    10 μg/ml treat 24h and 48h
    BTT 3033 4724

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