C 21

Name: C 21
Brand: Tocris Bioscience
SKU: 5128

Tocris Bioscience | Catalog # 5128

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Product Documents

Selective PRMT1 inhibitor

Discontinued Product

5128 has been discontinued. View all Protein Arginine Methyltransferase Inhibitors products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Selective PRMT1 inhibitor

View all Protein Arginine Methyltransferase Inhibitors »

Product Description

C 21 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.

Product Specifications for C 21

Molecular Weight

2166.94

Formula

C₉₀H₁₆₁ClN₃₆O₂₄

Storage

Store at -20°C

CAS Number

1229236-78-5

PubChem ID

46911727

InChI Key

OANJWIVLLOAGEG-CQSMXCMYSA-N

SMILES

CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(=N)CCl)NC(=O)CNC(=O)[C@H](CO)NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Mass

Concentration

音量

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g/mol

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Concentration 1 (C1)

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Concentration 2 (C2)

Volume 2 (V2)

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Obianyo and Thompson Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J.Biol.Chem. 2012 PMID: 22219200
Obianyo A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem 2010 PMID: 20480486

Product Documents for C 21

Certificate of Analysis

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Product Specific Notices for C 21

For research use only

Related Research Areas

Epigenetics

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