Caffeic acid phenethyl ester

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Caffeic acid phenethyl ester | CAS No. 104594-70-9 | NFkB/IkB Inhibitors
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Description: Specific inhibitor of NF-κB activation
Alternative Names: CAPE

Chemical Name: 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester

Purity: ≥98%

Product Details
Citations (11)

Biological Activity

Caffeic acid phenethyl ester is an antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF-κB activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties.
    Sud'ina et al.
    FEBS Lett., 1993;329:21
  2. Caffeic acid phenethyl ester, an inhibitor of nuclear factor-κB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats.
    Fitzpatrick et al.
    J.Pharmacol.Exp.Ther., 2001;299:915
  3. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB.
    Natarajan et al.
    Proc.Natl.Acad.Sci.USA, 1996;93:9090

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Citations for Caffeic acid phenethyl ester

The citations listed below are publications that use Tocris products. Selected citations for Caffeic acid phenethyl ester include:

11 Citations: Showing 1 - 10

  1. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
    Authors: Messerschmidt Et al.
    Mol Vis  2019;25:329
  2. HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β.
    Authors: Tawara Et al.
    Oncotarget  2019;10:2068
  3. Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
    Authors: Kleiner Et al.
    Mol Vis  2018;24:647
  4. A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.
    Authors: Ciarlo Et al.
    Elife  2017;6
  5. The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis.
    Authors: Mia and Bank
    PLoS Pathog  2016;363:775
  6. Transient blocking of NK cell function with small molecule inhibitors for helper dependant adenoviral vector-mediated gene delivery.
    Authors: Munegowda and Hu
    J Exp Clin Cancer Res  2015;5:29
  7. Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5.
    Authors: Hollborn Et al.
    Cell Biosci  2015;21:360
  8. Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA.
    Authors: Brosig Et al.
    Mol Vis  2015;21:1000
  9. Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.
    Authors: Ong Et al.
    Mol Vis  2015;11:e1004917
  10. Differential regulation of cyclin D1 expression by protein kinase C α and ε signaling in intestinal epithelial cells.
    Authors: Pysz Et al.
    J Biol Chem  2014;289:22268


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