Calphostin C

Name: Calphostin C
Brand: Tocris Bioscience
SKU: 1626
Price: 280 USD
Availability: InStock

Tocris Bioscience | Catalog # 1626

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Citations (57)

Product Documents

Potent, selective and photo-dependent PKC inhibitor

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent, selective and photo-dependent PKC inhibitor

Alternative Names

UCN 1028C,PKF 115584

View all Protein Kinase C Inhibitors »

Product Description

Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC₅₀ = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC₅₀ ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.

Product Specifications for Calphostin C

Molecular Weight

790.76

Formula

C₄₄H₃₈O₁₄

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester

CAS Number

121263-19-2

PubChem ID

6604893

InChI Key

SRJYZPCBWDVSGO-NHCUHLMSSA-N

SMILES

O=C1C(OC)=C(C[C@@H](C)OC(C2=CC=CC=C2)=O)C3=C4C5=C(C(OC)=CC(O)=C5C(C(OC)=C4C[C@@H](C)OC(OC6=CC=C(O)C=C6)=O)=O)C7=C(OC)C=C(O)C1=C73

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 57 publications citing the usage of this product.

Matsuzaki and Darcha In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis. PLoS One 2013 PMID: 23626717
Au Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J.Photochem.Photobiol.B. 2006 PMID: 16829117
Kobayashi Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem.Biophys.Res.Comm.
Pollack and Kawecki The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J.Neurooncol. 1997 PMID: 9049854

Product Documents for Calphostin C

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Calphostin C

For research use only

Related Research Areas

Diabetes

Intracellular Kinases

Citations for Calphostin C

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