Capzimin dimer

Key Product Details

Product Description

Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC₅₀ = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC₅₀ = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.

Product Specifications for Capzimin dimer

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Capzimin dimer

The following data is based on the product molecular weight 628.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.95 mL	15.90 mL
5 mM	0.32 mL	1.59 mL	3.18 mL
10 mM	0.16 mL	0.80 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Li Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat.Chem.Biol. 2017 PMID: 28244987
• Perez Discovery of an inhibitor of the proteasome subunit Rpn11. J.Med.Chem. 2017 PMID: 28191850

Product Documents for Capzimin dimer