CASIN

Key Product Details

Product Description

CASIN is a Cdc42 GTPase inhibitor (IC₅₀ = 2 μM). Reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs. Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo. Increases histone H4K16 acetylation in aged HSCs.

Product Specifications for CASIN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CASIN

The following data is based on the product molecular weight 306.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.26 mL	16.32 mL	32.64 mL
5 mM	0.65 mL	3.26 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.26 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

• Peterson Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem.Biol. 2006 PMID: 16632257
• Li Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 2013 PMID: 24012368
• Florian Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 2012 PMID: 22560076

Product Documents for CASIN