CB 5083

Key Product Details

Product Description

CB 5083 is a potent p97 inhibitor, inhibiting the D2 ATPase domain (IC₅₀ = 11 nM). CB 5083 shows broad antitumor activity and inhibits tumor growth in vivo. CB 5083 is cytotoxic to A549 cancer cells (IC₅₀ = 680 nM) and reduces cell viablility in a range of colorectal cancer cell lines. Increases CHOP and GRP78 protein levels, upregulates PD-L1 mRNA levels and results in the loss of aggresomes.

Product Specifications for CB 5083

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CB 5083

The following data is based on the product molecular weight 413.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.09 mL	24.18 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Le Moigne The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma. Mol.Cancer Ther. 2017 PMID: 28878026
• Huryn p97: an emerging target for cancer, neurodegenerative diseases, and viral infections. J.Med.Chem. 2019 PMID: 31550150
• Vekaria Targeting p97 to disrupt protein homeostasis in cancer. Front.Oncol. 2016 PMID: 27536557
• Vekaria Functional cooperativity of p97 and histone deacetylase 6 in mediating DNA repair in mantle cell lymphoma cells. Leukemia 2019 PMID: 30664664
• Mukkavalli The p97-UBXN1 complex regulates aggresome formation. J.Cell Sci. 2021 PMID: 33712450

Product Documents for CB 5083