CCG 1423

Tocris Bioscience | Catalog # 5233

Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs
Tocris Bioscience
Discontinued Product
5233 has been discontinued. View all Rho GTPase Inhibitors products.

Key Product Details

Description

Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs
View all Rho GTPase Inhibitors »

Product Description

CCG 1423 is a Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.

Product Specifications for CCG 1423

Molecular Weight

454.75

Formula

C18H13ClF6N2O3

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide

CAS Number

285986-88-1

PubChem ID

2726015

InChI Key

DSMXVSGJIDFLKP-UHFFFAOYSA-N

SMILES

O=C(NOC(C)C(NC2=CC=C(Cl)C=C2)=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.48 100

Preparing Stock Solutions for CCG 1423

The following data is based on the product molecular weight 454.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.20 mL 11.00 mL 21.99 mL
5 mM 0.44 mL 2.20 mL 4.40 mL
10 mM 0.22 mL 1.10 mL 2.20 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for CCG 1423

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CCG 1423

For research use only

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