CDDO-Me
Description: Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
Chemical Name: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester
Biological Activity
CDDO-Me is a Nrf2 pathway activator. Induces expression of Nrf-2 regulated, cytoprotective genes in vivo. Also blocks the NF-κB pathway by direct inhibition of IKKβ. Inhibits production of a wide range of inflammatory mediators in vitro.Technical Data
M.Wt:
505.69
Formula:
C32H43NO4
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at -20°C
CAS No:
218600-53-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Triterpenoid CDDO-Me blocks the NF-κB pathway by direct inhibition of IKKβ on Cys-179.
Ahmad et al.
J.Biol.Chem., 2006;281:35764 -
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.
Yates et al.
Mol.Cancer Ther., 2007;6:154 -
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.
Liby & Sporn
Pharmacol.Rev., 2012;64:972
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