Ceapin A7

Key Product Details

Product Description

Ceapin A7 is a selective inhibitor of ATF6α (IC₅₀=0.59 μM). The compound selectively inhibits ATF6α over ATF6β and other branches of the unfolded protein response (UPR). Ceapin A7 inhibits ER stress-induced upregulation of BiP in vitro. Ceapin A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.

Product Specifications for Ceapin A7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ceapin A7

The following data is based on the product molecular weight 470.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.63 mL	21.26 mL
5 mM	0.43 mL	2.13 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Gallagher and Walter Ceapins inhibit ATF6a signaling by selectively preventing transport of ATF6a to the Golgi apparatus during ER stress. eLife 2016 PMID: 27435962
• Gallagher Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. eLife 2016 PMID: 27435960

Product Documents for Ceapin A7