Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Biological ActivityCelastrol is an antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-α-induced NFκB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol.
Nagase et al.
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation.
Sethi et al.
Citation for Celastrol
The citations listed below are publications that use Tocris products. Selected citations for Celastrol include:
1 Citation: Showing 1 - 1
Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.
Authors: Zwicker Et al.
Clin Sci (Lond) 2015;129:281
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