Cevimeline hydrochloride

Key Product Details

Product Description

Cevimeline hydrochloride is a selective M₁ receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC₅₀ values are 3.5 and 3 μM respectively). Reverses AF64A-induced cognitive impairments in vivo.

Product Specifications for Cevimeline hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cevimeline hydrochloride

The following data is based on the product molecular weight 235.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.66 mL	28.28 mL	56.55 mL
3.75 mM	1.13 mL	5.66 mL	11.31 mL
7.5 mM	0.57 mL	2.83 mL	5.66 mL
37.5 mM	0.11 mL	0.57 mL	1.13 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Fisher (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M₁ selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease. J.Pharmacol.Exp.Ther. 1991 PMID: 2019998
• Hargreaves L-689,660, a novel cholinomimetic with functional selectivity for M₁ and M₃ muscarinic receptors. Br.J.Pharmacol. 1992 PMID: 1422595
• Wanibuchi Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur.J.Pharmacol. 1990 PMID: 1963596

Product Documents for Cevimeline hydrochloride