CGK 733

Key Product Details

Product Description

Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21^CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin-induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.

Product Specifications for CGK 733

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CGK 733

The following data is based on the product molecular weight 555.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.80 mL	9.00 mL	17.99 mL
5 mM	0.36 mL	1.80 mL	3.60 mL
10 mM	0.18 mL	0.90 mL	1.80 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Won Retraction: small molecule-based reversible reprogramming of cellular lifespan. Nat.Chem.Biol. 2008 PMID: 18560433
• Bhattacharya Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cell Signal. 2009 PMID: 19136059
• Alao and Sunnerhagen The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat.Oncol. 2009 PMID: 19903334
• Crescenzi Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: Implications for chemotherapy. Clin.Cancer Res. 2008 PMID: 18347191

Product Documents for CGK 733