CGP 60474

Key Product Details

Product Description

CGP 60474 is a potent cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 3 - 80, 9.5, 13, 17 - 60, 200 and 220 nM for cdk2, cdk5, cdk9, cdk1, cdk4 and cdk7, respectively). Also inhibits PKCα in the low micromolar range. Displays reversible G1/S cell cycle arrest in U2-OS cells.

Product Specifications for CGP 60474

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CGP 60474

The following data is based on the product molecular weight 355.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.05 mL	28.10 mL
5 mM	0.56 mL	2.81 mL	5.62 mL
10 mM	0.28 mL	1.41 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Sielecki Cyclin-dependent kinase inhibitors: useful targets in cell cycle regulation. J.Med.Chem. 2000 PMID: 10633033
• Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
• Stanetty Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J.Org.Chem. 2005 PMID: 15960526

Product Documents for CGP 60474