CGS 15943

Tocris Bioscience | Catalog # 1699

Potent adenosine receptor antagonist
Tocris Bioscience

Key Product Details

Description

Potent adenosine receptor antagonist
View all Non-selective Adenosine Receptor Antagonists »

Product Description

CGS 15943 is a potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively). Inhibits the catalytic subunit of the class IB PI3K isoform p110γ (IC50 = 1.1 μM). Blocks HCC and HDAC cell proliferation in vitro via inhibition of the PI3K/Akt pathway; reduces proliferation of ER+ breast cancer cells. Also acts as a BMP-4 mimetic to stimulate osteogenic differentiation. Orally active in vivo.

Product Specifications for CGS 15943

Molecular Weight

285.69

Formula

C13H8ClN5O

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

CAS Number

104615-18-1

PubChem ID

122070

InChI Key

JLPYLHLUHJOPNL-UHFFFAOYSA-N

SMILES

NC1=NC2=CC=C(Cl)C=C2C2=NC(=NN12)C1=CC=CO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.43 5

Preparing Stock Solutions for CGS 15943

The following data is based on the product molecular weight 285.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 70.01 mL 350.03 mL 700.06 mL
0.25 mM 14.00 mL 70.01 mL 140.01 mL
0.5 mM 7.00 mL 35.00 mL 70.01 mL
2.5 mM 1.40 mL 7.00 mL 14.00 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 66 publications citing the usage of this product.

Product Documents for CGS 15943

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGS 15943

For research use only

Customer Reviews for CGS 15943 (1)

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  • In vivo and in vitro use of CGS 15943
    Name: Ariel Vitenzon
    Species: Mouse
    Assay Type: In Vivo
    Cell Line/Tissue: systemic
    Verified Customer | Posted 01/05/2018
    Drug was dissolved using saline + 0.3% tween 80. (Vortexed for 1 minute and sonicated for 5 min) X3 times.
    This compound was used both in vivo and in vitro. For in vivo experiments we injected the compound systemically into transgenic mice and evaluated the effect of the drug on motor behavior. In vitro we used the drug on slices to evaluate the effect on the physiology of cells.

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