Ch 55

Tocris Bioscience | Catalog # 2020

Potent RAR agonist
Tocris Bioscience

Key Product Details

Description

Potent RAR agonist
View all Retinoic Acid Receptor Agonists »

Product Description

Ch 55 is a highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM). Enables generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from mouse embryonic fibroblasts (MEFs) (see our protocol below).

For more information about how Ch 55 may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Product Specifications for Ch 55

Molecular Weight

364.47

Formula

C24H28O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

4-[(1E)-3-[3,5-bis(1,1-Dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid

CAS Number

110368-33-7

PubChem ID

6184667

InChI Key

FOUVTBKPJRMLPE-FMIVXFBMSA-N

SMILES

CC(C)(C)C1=CC(=CC(=C1)C(=O)\C=C\C1=CC=C(C=C1)C(O)=O)C(C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.45 100
Ethanol 18.22 50

Preparing Stock Solutions for Ch 55

The following data is based on the product molecular weight 364.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 394 publications citing the usage of this product.

Product Documents for Ch 55

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ch 55

For research use only

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  • 42 perturbagens used the zebrafish DASPEI screen
    Name: Anonymous
    Species: Zebrafish
    Assay Type: In Vivo
    Cell Line/Tissue: larvae
    Verified Customer | Posted 12/17/2019
    Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound
    Ch 55 2020

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