CHIPOpt
Tocris Bioscience | Catalog # 8044
Key Product Details
Description
Product Description
CHIPOpt is a CHIP/STUB1 E3 ligase inhibitor. In vitro, CHIPOpt decreases phosphorylated tau ubiquitination, with little effect on unmodified tau. In Thioflavin T assays, CHIPOpt inhibits the ability of CHIP to suppress phosphorylated tau aggregation. FITC-CHIPOpt (Cat. No. 8045), a fluorescent CHIPOpt, is also available.
Product Specifications for CHIPOpt
Molecular Weight
Formula
Storage
Purity
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in 0.01M PBS |
Calculators
Background References
References are publications that support the biological activity of the product.
- Ravalin Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol. 2019 PMID: 31320752
- Nadel The E3 ubiquitin ligase, CHIP/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein tau (MAPT). J.Mol.Biol. 2023 PMID: 37330289
Product Documents for CHIPOpt
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for CHIPOpt
For research use only
Related Research Areas
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