Chlorisondamine diiodide
Discontinued Product
Chemical Name: 4,5,6,7-Tetrachloro-1,3-dihydro-2-methyl-2-[2-trimethylammonium)ethyl]-2H-isoindolium diiodide
Purity: ≥99%
Biological Activity
An exceptionally long lasting nicotinic antagonist (IC50 ~ 1.6 mM); blockade of central nicotinic responses induced by chlorisondamine can persist for several weeks.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
The pharmacology of the nicotinic antagonist, chlorisondamine investigated in rat brain and autonomic ganglion.
Clarke et al.
Br.J.Pharmacol., 1994;111:397 -
Blockade of nicotinic receptor-mediated release of DA from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro.
El-Bizri and Clarke
Br.J.Pharmacol., 1994;111:406 -
Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine.
El-Bizri and Clarke
Br.J.Pharmacol., 1994;113:917
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Citations for Chlorisondamine diiodide
The citations listed below are publications that use Tocris products. Selected citations for Chlorisondamine diiodide include:
4 Citations: Showing 1 - 4
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Angiotensin-dependent autonomic dysregulation precedes dilated cardiomyopathy in a mouse model of muscular dystrophy.
Authors: Sabharwal Et al.
J Exp Med 2015;100:776
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Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy.
Authors: Sabharwal Et al.
J Cereb Blood Flow Metab 2014;127:101
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Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function.
Authors: Bucci Et al.
Br J Pharmacol 2013;168:411
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Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve.
Authors: Luyer Et al.
Clin Sci (Lond) 2005;202:1023
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