Chloroquine diphosphate

Tocris Bioscience | Catalog # 4109

Antimalarial; inhibits apoptosis and autophagy
Tocris Bioscience

Key Product Details

Description

Antimalarial; inhibits apoptosis and autophagy
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Product Description

Chloroquine diphosphate is an antimalarial (Plasmodium) medicine. Inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Exhibits antimetastatic activity. Also inhibits autophagy via a mechanism distinct from that of 3-methyladenine (Cat. No. 3977). Blocks receptor-mediated endocytosis of mannose-glycoconjugates by macrophages. Inhibits SARS-CoV-2 infection in vitro (EC50 = 1.13 μM). Chloroquine improves efficacy of adeno-associated viral gene transduction in vivo and in vitro, as well as enhancing non-viral gene transfection in breast cancer cells.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Product Specifications for Chloroquine diphosphate

Molecular Weight

515.86

Formula

C18H26ClN3·2H3PO4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

CAS Number

50-63-5

PubChem ID

64927

InChI Key

QKICWELGRMTQCR-UHFFFAOYSA-N

SMILES

CCN(CC)CCCC(C)NC2=CC=NC1=CC(Cl)=CC=C12.O=P(O)(O)O.O=P(O)(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 51.59 100

Preparing Stock Solutions for Chloroquine diphosphate

The following data is based on the product molecular weight 515.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.69 mL 19.39 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 30 publications citing the usage of this product.

Product Documents for Chloroquine diphosphate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Chloroquine diphosphate

For research use only

Citations for Chloroquine diphosphate

Customer Reviews for Chloroquine diphosphate (1)

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  • Work great!
    Name: Hoang Le
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/06/2025
    This compound was used to inhibit autophagy in cells

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