CHPG

Tocris Bioscience | Catalog # 1049

mGlu5 selective agonist
Tocris Bioscience

Key Product Details

Description

mGlu5 selective agonist
View all Group I mGluR Agonists »

Product Description

CHPG is a selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Active in vivo.

Sodium Salt also available.

Product Specifications for CHPG

Molecular Weight

201.61

Formula

C8H8NO3Cl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

(RS)-2-Chloro-5-hydroxyphenylglycine

CAS Number

170846-74-9

PubChem ID

3645780

InChI Key

UNIDAFCQFPGYJJ-UHFFFAOYSA-N

SMILES

NC(C(O)=O)C1=CC(O)=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 20.16 100

Preparing Stock Solutions for CHPG

The following data is based on the product molecular weight 201.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.96 mL 24.80 mL 49.60 mL
5 mM 0.99 mL 4.96 mL 9.92 mL
10 mM 0.50 mL 2.48 mL 4.96 mL
50 mM 0.10 mL 0.50 mL 0.99 mL

Calculators

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Product Documents for CHPG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CHPG

For research use only

Customer Reviews for CHPG (1)

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  • Test of potential modulation of 5HT-1B receptor effects
    Name: Sergiy Sylantyev
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Arcuate nucleus
    Verified Customer | Posted 12/10/2023
    CHPG was used to test a (potential) impact of metabotropic glutamate receptors on the effect of 5HT-1B receptors on neurotransmitter vesicle release in interneuronal synapse. Picture: membrane capacitance fluctuation of living neuron after series of electrical stimuli delivered to acute neural tissue. Left: control. Right: activation of metabotropic glutamate receptors (with 1 μM CHPG, 1 μM (RS)-3,5-DHPG and 1 μM AMN 082), GABA-B receptors and ACh receptors does not show a significant effect. Grey traces: individual recordings; red: averaged trace.
    CHPG 1049

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