Ciclesonide

Key Product Details

Product Description

Ciclesonide is a glucocorticoid antiasthmatic prodrug; de-esterified in the lung to active metabolite. Anti-inflammatory. Also blocks replication of SARS-CoV-2 in Vero cells in vitro by targeting viral NSP-15 (EC₉₀ = 6.3μM)..

Product Specifications for Ciclesonide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ciclesonide

The following data is based on the product molecular weight 540.70.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.25 mL	18.49 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.18 mL	0.92 mL	1.85 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Matsuyama The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells. J.Virol. 2020 PMID: 33055254
• Stoeck In vitro and in vivo anti-inflammatory activity of the new glucocorticoid cicles. J.Pharmacol.Exp.Ther. 2004 PMID: 14718604

Product Documents for Ciclesonide