CID 16020046

Tocris Bioscience | Catalog # 4959

Selective GPR55 antagonist
Tocris Bioscience

Key Product Details

Description

Selective GPR55 antagonist
View all GPR55 Receptor Antagonists »

Product Description

CID 16020046 is a selective GPR55 antagonist. Inhibits LPI-induced Ca2+ signaling (IC50 = 0.21 μM in HEK-GPR55 cells), ERK1/2 phosphorylation and GPR55-mediated transcription factor activation. Displays weak inhibition of acetylcholinesterase, μ-opioid receptor, KCNH2 and hERG. Decreases LPI-induced GPR55 internalization. Reduces experimental intestinal inflammation in mice.

Product Specifications for CID 16020046

Molecular Weight

425.44

Formula

C25H19N3O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[4,6-Dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]benzoic acid

CAS Number

834903-43-4

PubChem ID

16020046

InChI Key

VGUQVYZXABOXCX-UHFFFAOYSA-N

SMILES

O=C1N(C5=CC=C(C(O)=O)C=C5)C(C4=CC=CC(O)=C4)C2=C1NN=C2C3=CC=C(C)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.54 100

Preparing Stock Solutions for CID 16020046

The following data is based on the product molecular weight 425.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.75 mL 23.51 mL
5 mM 0.47 mL 2.35 mL 4.70 mL
10 mM 0.24 mL 1.18 mL 2.35 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

Product Documents for CID 16020046

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CID 16020046

For research use only

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