Cilostamide

Key Product Details

Product Description

Cilostamide is a selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC₅₀ values are 0.027 and 0.050 μM for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC₅₀ = 16.8 μM); antithrombotic.

Product Specifications for Cilostamide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cilostamide

The following data is based on the product molecular weight 342.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.60 mL	73.01 mL	146.01 mL
1 mM	2.92 mL	14.60 mL	29.20 mL
2 mM	1.46 mL	7.30 mL	14.60 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 57 publications citing the usage of this product.

• Sudo Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem.Pharmacol. 2000 PMID: 10644042
• Christensen and Torphy Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents. Annu.Rep.Med.Chem.
• Hidaki Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation. J.Pharmacol.Exp.Ther. 1979 PMID: 226672

Product Documents for Cilostamide