Cimetidine

Key Product Details

Product Description

Cimetidine is a widely used H₂ histamine antagonist which has more recently been described as an inverse agonist. Also a potent I₁ imidazoline binding site ligand.

Product Specifications for Cimetidine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Cimetidine

The following data is based on the product molecular weight 252.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.96 mL	19.81 mL	39.63 mL
5 mM	0.79 mL	3.96 mL	7.93 mL
10 mM	0.40 mL	1.98 mL	3.96 mL
50 mM	0.08 mL	0.40 mL	0.79 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 34 publications citing the usage of this product.

• Ernsberger A second generation of centrally acting antihypertensive agents act on putative I₁-imidazoline receptors. J.Cardiovasc.Pharmacol.
• Smit Inverse agonism of histamine H₂ antagonists accounts for upregulation of spontaneously active receptors. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8692899
• Tsoli The imidazoline I₁ receptor agonist, moxonidine, inhibits Ins secretion from isolated rat islets of langerhans. Eur.J.Pharmacol. 1995 PMID: 8549627
• Hill Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 1990 PMID: 2164693

Product Documents for Cimetidine