cis-22a

Key Product Details

Product Description

cis-22a is a TRPV6 inhibitor (IC₅₀ = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

Product Specifications for cis-22a

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for cis-22a

The following data is based on the product molecular weight 563.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.87 mL	17.74 mL
5 mM	0.35 mL	1.77 mL	3.55 mL
10 mM	0.18 mL	0.89 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Simonin Optimization of TRPV6 calcium channel inhibitors using a 3D ligand-based virtual screening method. Angew.Chem.Int.Ed.Engl. 2015 PMID: 26457814
• Cunha Photoswitchable inhibitor of the calcium channel TRPV6. ACS Med.Chem.Lett. 2019 PMID: 31531207

Product Documents for cis-22a