cis-Ned 19

Tocris Bioscience | Catalog # 3953

NAADP antagonist; inhibits Ca2+ release
Tocris Bioscience
Discontinued Product
3953 has been discontinued. View all Calcium Signaling Agents products.

Key Product Details

Description

NAADP antagonist; inhibits Ca2+ release

Wavelength

Excitation = 368 nm, Emission = 425 nm
View all Calcium Signaling Agents »

Product Description

cis

-Ned 19 is an irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist; inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Stereoisomer of trans-Ned 19. Fluorescently labels NAADP receptors in intact cells (excitation 351 and 365 nm using an ultraviolet Argon laser).

Isomer of trans-Ned 19.

Optical Data

λabs 368 nm
λem 425 nm
Closest Laser line 355 nm
Cell Permeable Yes
Application Confocal Microscopy

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Product Specifications for cis-Ned 19

Molecular Weight

514.59

Formula

C30H31FN4O3

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

CAS Number

1137264-00-6

PubChem ID

1427626

InChI Key

FUHCEERDBRGPQZ-LSYYVWMOSA-N

SMILES

FC1=CC=CC=C1N(CC6)CCN6CC2=C[C@@]([C@H]3C4=C(C(C=CC=C5)=C5N4)C[C@@H]([C@@](O)=O)N3)=CC=C2OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.46 100

Preparing Stock Solutions for cis-Ned 19

The following data is based on the product molecular weight 514.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.72 mL 19.43 mL
5 mM 0.39 mL 1.94 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for cis-Ned 19

Certificate of Analysis

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Product Specific Notices for cis-Ned 19

For research use only

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