CK 869

Key Product Details

Product Description

CK 869 is an inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization (IC₅₀= 11 μM). Does not inhibit budding or fission yeast Arp2/3 complexes.

Product Specifications for CK 869

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CK 869

The following data is based on the product molecular weight 394.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.68 mL	25.36 mL
5 mM	0.51 mL	2.54 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Nolen Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 2009 PMID: 19648907
• Hetrick Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 PMID: 23623350

Product Documents for CK 869