CL 075

Key Product Details

Product Description

CL 075 is a TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat. No. 4287).

Product Specifications for CL 075

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CL 075

The following data is based on the product molecular weight 243.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.22 mL	41.10 mL	82.19 mL
2.5 mM	1.64 mL	8.22 mL	16.44 mL
5 mM	0.82 mL	4.11 mL	8.22 mL
25 mM	0.16 mL	0.82 mL	1.64 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Pang Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 2011 PMID: 21962237
• Spranger Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 2010 PMID: 20511554
• Gorden Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 2005 PMID: 15661881

Product Documents for CL 075