Cl-4AS-1

Tocris Bioscience | Catalog # 3812

Steroidal androgen receptor agonist
Tocris Bioscience

Key Product Details

Description

Steroidal androgen receptor agonist
View all Androgen Receptor Agonists »

Product Description

Cl-4AS-1 is a potent steroidal androgen receptor agonist (IC50 = 12 nM). Mimics the action of 5α-dihydrotestosterone (DHT). Transactivates the mouse mammary tumor virus (MMTV) promoter; represses MMP1 promoter activity. Inhibits 5α-reductase type I and II (IC50 values are 6 and 10 nM respectively).

Product Specifications for Cl-4AS-1

Molecular Weight

441.01

Formula

C26H33ClN2O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide

CAS Number

188589-66-4

PubChem ID

90488881

InChI Key

CTVXDPDUOKQBKZ-BLIBDJTASA-N

SMILES

O=C(NC1=CC=CC=C1Cl)[C@H]2CC[C@@]3([H])[C@]4([H])CC[C@@]5([H])N(C)C(C=C[C@]5(C)[C@@]4([H])CC[C@@]32C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.41 10
Ethanol 4.41 10

Preparing Stock Solutions for Cl-4AS-1

The following data is based on the product molecular weight 441.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.68 mL 113.38 mL 226.75 mL
0.5 mM 4.54 mL 22.68 mL 45.35 mL
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for Cl-4AS-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Cl-4AS-1

For research use only

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