CM 10

Key Product Details

Product Description

CM 10 is a aldehyde dehydrogenase 1A (ALDH1A) inhibitor (IC₅₀ values are 0.64, 0.74 and 1.7 μM for ALDH1A3, ALDH1A2 and ALDH1A1, respectively). Induces a necroptotic phenotype and preferentially depletes CD133⁺ ovarian cancer stem cells in vitro.

Product Specifications for CM 10

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CM 10

The following data is based on the product molecular weight 321.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.11 mL	15.56 mL	31.11 mL
5 mM	0.62 mL	3.11 mL	6.22 mL
10 mM	0.31 mL	1.56 mL	3.11 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Morgan & Hurley Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. Chem.Biol.Interact. 2015 PMID: 25450233
• Chefetz A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells. Cell Rep. 2019 PMID: 30865894

Product Documents for CM 10