CMPD-1

Tocris Bioscience | Catalog # 2186

Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor
Tocris Bioscience
Discontinued Product
2186 has been discontinued. View all p38 Inhibitors products.

Key Product Details

Description

Selective inhibitor of p38α-mediated MK2a phosphorylation; also tubulin polymerization inhibitor
View all p38 Inhibitors »

Product Description

CMPD-1 is a non-ATP-competitive, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-2a) phosphorylation (apparent Ki = 330 nM). Does not inhibit p38α-mediated phosphorylation of MBP and ATF-2. Also tubulin polymerization inhibitor. Cytotoxic in glioblastoma cells at concentrations that do not affect the MK2 pathway.

Product Specifications for CMPD-1

Molecular Weight

349.40

Formula

C22H20FNO2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2'-Fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide

CAS Number

41179-33-3

PubChem ID

11382492

InChI Key

ODYAQBDIXCVKAE-UHFFFAOYSA-N

SMILES

OC1=CC=C(NC(=O)CCCC2=CC=C(C=C2)C2=CC=CC=C2F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.94 100
Ethanol 34.94 100

Preparing Stock Solutions for CMPD-1

The following data is based on the product molecular weight 349.40.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.31 mL 28.62 mL
5 mM 0.57 mL 2.86 mL 5.72 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for CMPD-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CMPD-1

For research use only

Customer Reviews for CMPD-1 (1)

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  • 42 perturbagens used the zebrafish DASPEI screen
    Name: Anonymous
    Species: Zebrafish
    Assay Type: In Vivo
    Cell Line/Tissue: larvae
    Verified Customer | Posted 12/17/2019
    Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound
    CMPD-1 2186

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