CMPI hydrochloride

Key Product Details

Product Description

CMPI hydrochloride is a potent positive allosteric modulator of α4β2 nAChRs (EC₅₀ values are 20 and 18 nM for rat and human, respectively). Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)₂(β2)₃, muscle-type and Torpedo nAChRs (IC₅₀ values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)₃(β2)₂ receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains.

Product Specifications for CMPI hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CMPI hydrochloride

The following data is based on the product molecular weight 379.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.18 mL	26.37 mL
5 mM	0.53 mL	2.64 mL	5.27 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Albrecht Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators. Bioorg.Med.Chem.Lett. 2008 PMID: 18789861
• Wang Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses. J.Biol.Chem. 2017 PMID: 28446611
• Hamouda Photolabeling a nicotinic acetylcholine receptor (nAChR) with an (α4)₃(β2)₂ nAChR-selective positive allosteric modulator. Mol.Pharmacol. 2016 PMID: 26976945

Product Documents for CMPI hydrochloride