Co 102862
Discontinued Product
Chemical Name: 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
Purity: ≥99%
Biological Activity
Co 102862 is a broad spectrum, state-dependent blocker of voltage-gated sodium channels. Displays ~ 80-fold higher affinity for inactivated Na+ channels compared to channels in the resting state. Anticonvulsant; displays activity in rodent models of tonic/clonic and partial-complex seizures.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels.
Ilyin et al.
Br.J.Pharmacol., 2005;144:801 -
Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.
Ilyin et al.
J.Pharmacol.Exp.Ther., 2006;318:1083
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