Colchicine

Tocris Bioscience | Catalog # 1364

Inhibitor of tubulin
Tocris Bioscience

Key Product Details

Description

Inhibitor of tubulin
View all Microtubule Binding Compounds »

Product Description

Colchicine is a plant-derived alkaloid that binds to tubulin and depolymerizes microtubules. Identified as a candidate for repurposing for COVID-19. Inhibits NLRP3 inflammasomes. Also decreases TNF-α receptor expression and reduces cytokine levels in macrophages. Anti-inflammatory.

Product Specifications for Colchicine

Molecular Weight

399.44

Formula

C22H25NO6

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

CAS Number

64-86-8

PubChem ID

2833

InChI Key

IAKHMKGGTNLKSZ-UHFFFAOYSA-N

SMILES

COC1=C(OC)C(OC)=C2C(CCC(NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 39.94 100
DMSO 39.94 100

Preparing Stock Solutions for Colchicine

The following data is based on the product molecular weight 399.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.50 mL 12.52 mL 25.04 mL
5 mM 0.50 mL 2.50 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.50 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 37 publications citing the usage of this product.

Product Documents for Colchicine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Colchicine

For research use only

⚠ WARNING: This product can expose you to chemicals including Colchicine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Related Research Areas

Microtubules

Customer Reviews for Colchicine (1)

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  • Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone screen for Human epidermal carcinoma
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human epidermal carcinoma cell line
    Verified Customer | Posted 11/17/2019
    Human epidermal carcinoma cell line was treated with Paclitaxel, docetaxel, vincristine, vinblastine, colchicine, cisplatin, and mitoxantrone which purchased from Tocris Bioscience.
    Colchicine 1364

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