Colivelin

Tocris Bioscience | Catalog # 3945

STAT3 activator; also protects against β-amyloid neurotoxicity
Tocris Bioscience

Key Product Details

Description

STAT3 activator; also protects against β-amyloid neurotoxicity
View all Amyloid beta Peptides »

Product Description

Colivelin is a neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.

Product Specifications for Colivelin

Molecular Weight

2645.13

Formula

C119H206N32O35

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

867021-83-8

PubChem ID

90477169

InChI Key

PTTAQOYOJJTWFD-IBAOLXMASA-N

SMILES

[H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in 20% ethanol / water

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Product Documents for Colivelin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Colivelin

For research use only

Customer Reviews for Colivelin (1)

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  • Test
    Name: Manuel Jesús Pérez Baena
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HC11
    Verified Customer | Posted 02/05/2026
    Do not vortex vigorously after reconstitution.
    We wanted to evaluate the effect of STAT3 activation on lactogenic differentiation in the HC11 cell line. The HC11 cell line was treated with 1 uM Colivelin, the STAT3 activator, for 1 hour. We first evaluated the degree of activation of this protein after treatment by western blot. After 1 hour, STAT3 activation was potent.
    Colivelin 3945

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