Colivelin

Name: Colivelin
Brand: Tocris Bioscience
SKU: 3945
Price: 406 USD
Availability: InStock

Tocris Bioscience | Catalog # 3945

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Citations (18)

Product Documents

STAT3 activator; also protects against β-amyloid neurotoxicity

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

STAT3 activator; also protects against β-amyloid neurotoxicity

View all Amyloid beta Peptides »

Product Description

Colivelin is a neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant.

Product Specifications for Colivelin

Molecular Weight

2645.13

Formula

C₁₁₉H₂₀₆N₃₂O₃₅

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

867021-83-8

PubChem ID

90477169

InChI Key

PTTAQOYOJJTWFD-IBAOLXMASA-N

SMILES

[H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 20% ethanol / water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 18 publications citing the usage of this product.

Sari A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 2009 PMID: 19782727
Yamada Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 2008 PMID: 17928813
Chiba Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo J.Neurosci. 2005 PMID: 16267233

Product Documents for Colivelin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Colivelin

For research use only

Citations for Colivelin

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