Combretastatin A4
Chemical Name: 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
Purity: ≥99%
Biological Activity
Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Potent anti-metastatic activity of combretastatin-A4.
Griggs et al.
Int.J.Oncol., 2001;19:821 -
Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor.
Dorr et al.
Invest.New Drugs, 1996;14:131 -
Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells.
Lin et al.
J.Pharmacol.Exp.Ther., 2007;323:365
Product Datasheets
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Citations for Combretastatin A4
The citations listed below are publications that use Tocris products. Selected citations for Combretastatin A4 include:
2 Citations: Showing 1 - 2
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Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Authors: Meseke Et al.
Eneuro 2018;5
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Novel microtubule polymerization inhibitor with potent antiproliferative and antitumor activity.
Authors: Arora Et al.
J Biol Chem 2009;69:1910
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