Cortistatin 14

Name: Cortistatin 14
Brand: Tocris Bioscience
SKU: 3374
Price: 338 USD
Availability: InStock

Tocris Bioscience | Catalog # 3374

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Product Documents

Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Endogenous neuropeptide; binds sst1 - sst5, ghrelin receptor and MRGPRX2

Alternative Names

CST-14

View all Additional Somatostatin Receptor Peptides »

Product Description

Cortistatin 14 (CST-14) is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst₁ - sst₅) and prevents somatostatin-14 binding (IC₅₀ values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst₂, sst₄, sst₃, sst₅ and sst₁ receptors, respectively). Also a potent MRGPRX2 agonist (EC₅₀ = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a). Exhibits neuronal depressant and sleep-modulating properties in vivo.

Product Specifications for Cortistatin 14

Molecular Weight

1721.03

Formula

C₈₁H₁₁₃N₁₉O₁₉S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

193829-96-8

PubChem ID

16133803

InChI Key

DDRPLNQJNRBRNY-WYYADCIBSA-N

SMILES

[H]N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.7mg/ml in water

Calculators

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Mass

Concentration

音量

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g/mol

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Background References

References are publications that support the biological activity of the product.

Robas MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J.Biol.Chem. 2003 PMID: 12915402
Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Fukusumi Identification and characterization of a novel human cortisan-like peptide. Biochem.Biophys.Res.Comm. 1997 PMID: 9125122
Spier and de Lecea Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res. 2000 PMID: 11011067
Deghenghi Cortistatin, but not somatostatin, binds to GH secretagogue (GHS) receptors of the human pituitary gland. J.Endocrinol.Invest. 2001 PMID: 11227737

Product Documents for Cortistatin 14

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Cortistatin 14

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Citations for Cortistatin 14

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