CPPG

Tocris Bioscience | Catalog # 0972

Potent group III mGlu antagonist
Tocris Bioscience

Key Product Details

Description

Potent group III mGlu antagonist
View all Group III mGluR Antagonists »

Product Description

CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). A much less potent antagonist at group I receptors in neonatal rat cortical slices (KB = 0.65 ± 0.07 nM).

Product Specifications for CPPG

Molecular Weight

271.21

Formula

C11H14NO5P

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(RS)-α-Cyclopropyl-4-phosphonophenylglycine

CAS Number

183364-82-1

PubChem ID

2878

InChI Key

IGODGTDUQSMDQU-UHFFFAOYSA-N

SMILES

NC(C2CC2)(C(O)=O)C1=CC=C(P(O)(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 27.12 100

Preparing Stock Solutions for CPPG

The following data is based on the product molecular weight 271.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.44 mL 36.87 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 111 publications citing the usage of this product.

Product Documents for CPPG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CPPG

For research use only

Customer Reviews for CPPG (2)

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  • Used in inhibitor cocktail
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Retinal rod bipolar cells
    Verified Customer | Posted 12/03/2019
    Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail - 600 umol/L
    CPPG 0972
  • Use of CPPG as a blocker of mGluRs group III
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Cerebellum
    Verified Customer | Posted 09/17/2019
    Compound should be sonicated when dissolving.
    CPPG (5 microM) was used for pharmacological isolation of GABA-A receptor activity in nucleated membrane patches. Being added to perfusion solution, CPPG blocked contaminating receptor activity in a recorded response, thus revealing clear GABA-ergic single-channel openings. Figure: single-channel openings of GABA-A receptors in a membrane patch after application of CPPG.
    CPPG 0972

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