CPS2

Key Product Details

Product Description

CPS2 is a potent and selective CDK2 Degrader (PROTAC^®) (IC₅₀ = 24 nM). It induces CDK2 degradation in several AML cell lines, including NB4, U937, OCI-AML2, OCI-AML3 and Kasumi-1 cells. It induces differentiation of AML cell lines, primary AML cells, and granulocytic differentiation of HSCs.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for CPS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CPS2

The following data is based on the product molecular weight 890.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.12 mL	5.61 mL	11.22 mL
5 mM	0.22 mL	1.12 mL	2.24 mL
10 mM	0.11 mL	0.56 mL	1.12 mL
50 mM	0.02 mL	0.11 mL	0.22 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wang Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy. Nat.Chem.Biol. 2021 PMID: 33664520

Product Documents for CPS2