CPYPP

Tocris Bioscience | Catalog # 4568

DOCK2-Rac1 interaction inhibitor
Tocris Bioscience

Key Product Details

Description

DOCK2-Rac1 interaction inhibitor
View all Rho GTPase Inhibitors »

Product Description

CPYPP is a DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.

Product Specifications for CPYPP

Molecular Weight

324.76

Formula

C18H13ClN2O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione

CAS Number

310460-39-0

PubChem ID

2248187

InChI Key

VVZJFICTTKPNCK-XWDZFIQBSA-N

SMILES

O=C(N(C3=CC=CC=C3)NC2=O)/C2=C\C=C\C1=C(Cl)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.5 20

Preparing Stock Solutions for CPYPP

The following data is based on the product molecular weight 324.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 15.40 mL 76.98 mL 153.96 mL
1 mM 3.08 mL 15.40 mL 30.79 mL
2 mM 1.54 mL 7.70 mL 15.40 mL
10 mM 0.31 mL 1.54 mL 3.08 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for CPYPP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CPYPP

For research use only

Customer Reviews for CPYPP (1)

4 out of 5
1 Customer Rating
5 Stars
0%
4 Stars
100%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used CPYPP?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 的 1 review Showing All
Filter By:
Clear Filters X
  • Inhibits cell migration
    Name: Kishor Pant
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HepG2, and Huh
    Verified Customer | Posted 03/24/2023
    CPYPP inhibited cell migration in HCC in vitro. Image: top panel shows result at 0 h; bottom panel at 48 h.
    CPYPP 4568

There are no reviews that match your criteria.

Showing  1 - 1 的 1 review Showing All