CST 626

Tocris Bioscience | Catalog # 8021

Potent pan IAP Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent pan IAP Degrader (PROTAC®)
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Product Description

CST 626 is a potent IAP Degrader (PROTAC®) (DC50 values at 16 hours are 0.7 nM, 2.4 nM and 6.2 nM at XIAP, cIAP1 and cIAP2 respectively; Dmax = 90-99%). Reduces cell viability in some cell types, including SUDHL6 and MOLM13 (IC50 values are 16 nM and 21 nM respectively).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for CST 626

Molecular Weight

1103.43

Formula

C61H82N8O9S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-(3-((5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)oxy)phenoxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide

CAS Number

3033993-13-1

InChI Key

SMENADKMMXTZAZ-FMVATYOPSA-N

SMILES

O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)C[C@@H](OC3=CC(OCCCCC(N[C@H](C(N4C[C@H](O)C[C@H]4C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)C(C)(C)C)=O)=CC=C3)C1)N[C@@H]7CCCC8=CC=CC=C87

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 110.34 100

Preparing Stock Solutions for CST 626

The following data is based on the product molecular weight 1103.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.91 mL 4.53 mL 9.06 mL
5 mM 0.18 mL 0.91 mL 1.81 mL
10 mM 0.09 mL 0.45 mL 0.91 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Product Documents for CST 626

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CST 626

For research use only

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