CST 905

Tocris Bioscience | Catalog # 7745

Potent and selective BRAFV600E Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent and selective BRAFV600E Degrader (PROTAC®)
View all Active Degraders »

Product Description

CST 905 is a potent and selective BRAFV600E Degrader (PROTAC®) (DC50 = 18 nM). CST 905 comprises a ligand for the von Hippel Lindau (VHL) E3 ligase joined by a linker to a PLX-derived ligand. Unlike other BRAFV600E Degraders, CST 905 does not activate ERK.

B-Raf antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF3424.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for CST 905

Molecular Weight

1025.20

Formula

C51H58F2N10O7S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2S,4R)-1-((S)-2-(2-(4-(4-(3-(3-((N-Ethyl-N-methylsulfamoyl)amino)-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

InChI Key

VOFGLMSAVUMRLF-FGUOTCRGSA-N

SMILES

FC1=C(C(F)=CC=C1NS(N(C)CC)(=O)=O)C(C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)N5CCN(CC5)CC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 102.52 100

Preparing Stock Solutions for CST 905

The following data is based on the product molecular weight 1025.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.98 mL 4.88 mL 9.75 mL
5 mM 0.20 mL 0.98 mL 1.95 mL
10 mM 0.10 mL 0.49 mL 0.98 mL
50 mM 0.02 mL 0.10 mL 0.20 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CST 905

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CST 905

For research use only

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