CTA 056

Tocris Bioscience | Catalog # 4726

ITK inhibitor
Tocris Bioscience

Key Product Details

Description

ITK inhibitor
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Product Description

CTA 056 is an interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.

Product Specifications for CTA 056

Molecular Weight

554.68

Formula

C35H34N6O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one

CAS Number

1265822-30-7

PubChem ID

49870925

InChI Key

BSSBAJKNZOHHCA-UHFFFAOYSA-N

SMILES

O=C2C(CC7=CC=CC=C7)=NC1=CC3=C(N=C(C5=CC=C(C6=CC=NC=C6)C=C5)N3CCCN4CCCCC4)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.55 10 with gentle warming

Preparing Stock Solutions for CTA 056

The following data is based on the product molecular weight 554.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.14 mL 180.28 mL
0.5 mM 3.61 mL 18.03 mL 36.06 mL
1 mM 1.80 mL 9.01 mL 18.03 mL
5 mM 0.36 mL 1.80 mL 3.61 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for CTA 056

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CTA 056

For research use only

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  • T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: T cell line
    Verified Customer | Posted 03/26/2020
    10uM
    CTA 056 4726

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