CTOP

Tocris Bioscience | Catalog # 1578

Submit a review

Citations (73)

Product Documents

Potent and selective μ antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective μ antagonist

View all mu Opioid Receptor Antagonists »

Product Description

CTOP is a potent and selective μ opioid receptor antagonist (K_i values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo. Also increases K⁺ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.

Product Specifications for CTOP

Molecular Weight

1062.28

Formula

C₅₀H₆₇N₁₁O₁₁S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

103429-31-8

PubChem ID

90479805

InChI Key

PZWWYAHWHHNCHO-KOFBULAQSA-N

SMILES

[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC(C)(C)C(NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

音量

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 73 publications citing the usage of this product.

Chieng The μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a no Mol.Pharmacol. 1996 PMID: 8794906
Gulya Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH² (CTOP) in mice. Eur.J.Pharmacol. 1988 PMID: 2901358
Hawkins [³H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH₂] ([³H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain. J.Pharmacol.Exp.Ther. 1989 PMID: 2563293
Badiani Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity. Brain Res. 1995 PMID: 7496796

Product Documents for CTOP

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for CTOP

For research use only

Citations for CTOP

Customer Reviews for CTOP

There are currently no reviews for this product. Be the first to review CTOP and earn rewards!

Have you used CTOP?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image