CU-T12-9

Tocris Bioscience | Catalog # 5414

Potent TLR1/2 agonist
Tocris Bioscience

Key Product Details

Description

Potent TLR1/2 agonist
View all Toll-like Receptor Agonists »

Product Description

CU-T12-9 is a potent TLR1/2 agonist (EC50 = 52.9 nM). Activates the NF-κB pathway and upregulates proinflammatory cytokines in vitro. Also enhances TLR1 and TLR2 dimerization.

Licensing Information

Sold under license from the University of Colorado

Product Specifications for CU-T12-9

Molecular Weight

362.31

Formula

C17H13F3N4O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-Methyl-4-nitro-2-(4-(4-trifluoromethyl)phenyl)-1H-imidazol-1-yl)aniline

CAS Number

1821387-73-8

PubChem ID

91826088

InChI Key

LITXVDAFEYLWQE-UHFFFAOYSA-N

SMILES

CNC1=CC=C([N+]([O-])=O)C=C1N2C=C(C3=CC=C(C(F)(F)F)C=C3)N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.23 100
Ethanol 7.25 20

Preparing Stock Solutions for CU-T12-9

The following data is based on the product molecular weight 362.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.80 mL 27.60 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for CU-T12-9

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CU-T12-9

For research use only

Customer Reviews for CU-T12-9 (1)

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  • activation of NF-kappa B pathway in presence of CUt-12-9
    Name: Tahmineh Safaie
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Raw-Blue
    Verified Customer | Posted 02/28/2020
    Raw-Blue cell lines were treated with different concentration of CU-T129 for 24 hours and the level of Seap was measured
    CU-T12-9 5414

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