Biological ActivityCyclotraxin B is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
(Modification: Disulfide bridge: 1-11)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice.
Constandil et al.
Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice.
Cazorla et al.
PLoS One, 2010;5:e9777
Citations for Cyclotraxin B
The citations listed below are publications that use Tocris products. Selected citations for Cyclotraxin B include:
2 Citations: Showing 1 - 2
Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.
Authors: Merk Et al.
Dev Cell 2018;44:709
BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
Authors: Zhong Et al.
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
VersaClone cDNA Plasmids
Reviews for Cyclotraxin B
There are currently no reviews for this product. Be the first to review Cyclotraxin B and earn rewards!
Have you used Cyclotraxin B?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image