D 927

Key Product Details

Product Description

D 927 is a molecular glue increasing the binding affinity of phosphoinositide 3-kinase α (PI3Kα) catalytic subunit p110α (Kd = 5.6 μM) to canonical small guanosine triphosphatase RAS proteins and to RRAS, RRAS2, and MRAS by three orders of magnitude. Binds to the RAS-binding domain of p110α, stabilizing the secondary structures of the PI3Kα in a RAS-binding conformation and forming direct interactions with RAS residues tyrosine-40 and arginine-41. In vivo, D 927 mimicks insulin, lowering blood glucose concentrations, enhancing glucose metabolism in normal and Zucker fatty rats, and improving hyperglycemia in models of type 1 and type 2 diabetes, even in insulin-deficient diabetic animals. D 927 is orally bioavailable.

Product Specifications for D 927

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for D 927

The following data is based on the product molecular weight 452.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.05 mL	22.10 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Terayama Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin. Science 2025 PMID: 40705882

Product Documents for D 927